Motor neurone illness (MND) is a progressive illness that attacks the motor neurones, or nerves, inwards the encephalon as well as spinal cord. This agency messages gradually halt reaching muscles, which leads to weakness as well as wasting.
Motor neuron diseases are characterized past times selective degeneration of motor neurons, both upper as well as lower, namely of the pyramidal fibers inwards cerebral cortex, of ventral horn cells as well as of cranial motor nervus nuclei. In different cases relative incidence of degeneration varies. In simply about the modify is maximal inwards the ventral horn cells, inwards others inwards the cranial nervus nuclei, inwards others pyramidal fiber sclerosis is severe as well as adds the appropriate clinical picture.
MND tin comport upon how you lot walk, talk, eat, potable as well as breathe. However, non all symptoms necessarily hap to everyone as well as it is unlikely they volition all develop at the same time, or inwards whatever specific order.
RISK FACTORS
· Hereditary- There is a genetic link involved inwards developing this condition
· Age-Usually after the historic current of 40, remove chances of developing MND increases
· Sex- MND is to a greater extent than mutual inwards males than females
· Certain professions- People who are working inwards army, navy or air strength bring shown higher remove chances of developing MND. Professional human foot ball players are also flora to bring much higher remove chances of developing MND
CAUSES--About five % of cases are familial, showing autosomal dominant inheritance. In many such families genetic defects lies on chromosome 21, the enzyme involved beingness a superoxide dismutase (SOD1).
For the remaining 95 percentage likely causes includes
· Chronic Aluminum toxicity
· Slow virus infection
· Auto immunity
· Trauma
· Electrical shock
Another suggestive hypothesis is that glutamate which is a primary excitatory neurotransmitter inwards the CNS, accumulates at synapses as well as causes the neurons to die, in all probability through a calcium dependent mechanism. Prevalence of this illness is virtually 5/100000.
CLASSIFICATION-
MND tin live on divided into iv primary groups
· Amyotrophic lateral sclerosis ( ALS )
· Progressive bulbar palsy (PBP )
· Progressive muscular atrophy (PMA)
· Primary lateral sclerosis ( PLS )
Out of these four, the ALS (Amyotrophic lateral sclerosis) is the most mutual shape of MND. Its prevalence is to a greater extent than than 65%. It is also known every bit Lou Gehriga's disease. This lift is given after the famous footballer Lou Gehrig, who also suffered from this disease.
SYMPTOMS
Limbs musculus weakness, cramps, occasionally fasciculation.
Disturbance of speech communication as well as swallowing (dysarthria as well as dysphagia )
SIGNS
Wasting as well as fasciculation of muscles
Weakness of muscles of limbs as well as tongue, human face upwards as well as palate.
Pyramidal tract interest causes spasticity, exaggerated tendon reflexes as well as extensor plantar responses.
External occular muscles as well as sphincters ordinarily stay intact.
No objective sensory deficit.
No intellectual terms inwards most cases.
Disturbance of speech communication as well as swallowing (dysarthria as well as dysphagia )
SIGNS
Wasting as well as fasciculation of muscles
Weakness of muscles of limbs as well as tongue, human face upwards as well as palate.
Pyramidal tract interest causes spasticity, exaggerated tendon reflexes as well as extensor plantar responses.
External occular muscles as well as sphincters ordinarily stay intact.
No objective sensory deficit.
No intellectual terms inwards most cases.
HOMOEOPATHIC REMEDIES
PLUMBUM METALLICUM 200-Plumbum metallicum is ane of the hand remedies for MND. Paralysis alongside atrophy. Muscular atrophy from sclerosis of spinal system. Excessive as well as rapid emaciation. General or partial paralysis alongside peachy weakness as well as anaemia. Clonic or tonic spasm from cerebral sclerosis or tumor. Paralysis of plumbum is prominently of spinal origin. Paralysis of upper extremities is to a greater extent than marked. Ptosis. Heavy tongue. Difficulty inwards articulation. Tremor of nasolabial muscles. Twitching of the side of the face. Paralysis of gullet as well as inability to swallow. Paralysis of lower extremities alongside paralysis of unmarried muscle. Paralysis from over exertion.
CAUSTICUM 200-Causticum is an effective remedy MND. Paralysis of unmarried parts- song organs, tongue, eyelids, face, bladder, extremities, to a greater extent than often than non of rt sided. Paralysis from exposure to mutual frigidness air current or draft. Paralysis after typhoid, typhus or diphtheria;appearing. Drooping of optic lids,cannot travel along them open. It is used inwards paralysis which is remote from apoplexy, the paralysis remaining after patient has recovered from apoplexy alongside inability to remove proper words. Laryngeal muscles turn down their services, cannot speak a loud word. Aphonia. Sudden aphonia after taking cold. Paralysis of human face upwards or natural language or hemiplegia alongside giddiness, weakness of sight, weeping mood, hopelessnessand fright of death.
GUACO 30-Guaco is simply about other effective remedy for MND. Acts on nervous system. Bulbar paralysis. Deafness. Tongue heavy as well as hard to move. Spinal irritation.Spinal symptoms are most marked. Beer drinkers threatened alongside apoplexy. Larynx as well as trachea are constricted. Difficult deglutition. Paralysis of lower extremities.
MANGANUM OXYDATUM 200-Manganum oxydatum is also effective for MND. Low monotonous voice. Economical speech. Mask similar facies. Muscular twitching. Cramps inwards calves Stiff leg muscles. Occasional uncontrollable laughter. Peculiar slapping gait. Workers of manganum binoxide are oft affected alongside bulbar paralysis. Pseudo sclerosis. Progressive lenticular degeneration. Similar symptoms to paralysis agitance.
COCCULUS 200-Paralysis of facial nervus specially of ane side. Or natural language pharynx. Paraplegia as well as rheumatic lamness inwards weakened or nervous subjects, who are inclined fainting fits as well as palpitation of the heart. Paralytic affection originates inwards the modest of the dorsum after taking cold, alongside mutual frigidness feeling of extremities as well as edema of the feet. Paralysis after apoplexy. Paralysis of lower limbs. Paralytic immobility. One sided paralysis of the human face upwards alongside cramp similar hurting inwards masseter < opening the mouth. Prosopalgia. Tremor of lower jaw as well as chattering of teeth when attempting to speak. Lines of human face upwards are deepened every bit if drawn. Paralysis of the natural language alongside hard speech. Pains at the base of operations of the natural language when protruded. Paralysis of muscles of deglutition alongside difficulty to swallow.
GELSEMIUM 200-Complete motor paralysis, rather functional than organic inwards nature. Paralysis of occular muscles. Ptosis. Paretic status of the natural language causes difficulty to speak. Speak is thick. Paralysis from emotions. Post diphtheritic paralysis. Paralysis of larynx causes aphonia. Locomotor ataxia. Paraplegia.
LACHESIS 200-Especially left side. Awkward. Stumbling gait. Paralysis after apoplexy. Trifacial neuralgia. Spasm of glottis.
NUX VOMICA 200-- Incomplete paralysis of the face, arms, as well as legs alongside vertigo, weak memory, darkness earlier the eyes, ringing inwards ears, loss of appetite, burning inwards stomach, flatulence as well as vomiting after eating as well as drinking.Constipation specially inwards drunkards. Jaw contracted. Infra orbital neuralgia. Left angle of the oral cavity drops. Twitching as well as spasmodic distortion of face. Articulation as well as speech communication difficult. Paralysis of arms. Automatic motion
OPIUM 200-Paralysis as well as insensibility after apoplexy, inwards drunkards, inwards onetime people, associated alongside retention of stool as well as urine. Spasmodic facial twitching, specially of corners of mouth. Hanging downwardly of lower jaw. Distorted face. Twitching of facial muscles. Face covered alongside profuse sweat. Paralysed natural language which dry out as well as black. Difficult joint as well as swallowing. Tongue protrudes to correct side. Inability to swallow. On swallowing nutrient goes the incorrect way or returns through nose. Painless paralysis. Twitching of limbs. Numbness. Jerks every bit if flexors are overacting. Sensation every bit if lower limbs were severed as well as belongs to individual else. Shifting as well as trembling gait. One or other arm moves convulsively to as well as fro. Coldness of extremities.
STRAMONIUM 200- Paralysis after convulsion,. Paralysis of ane or spasm of other side. Stammering speech. Cannot swallow on trouble organization human relationship of spasm.
GRAPHITES 200-Rheumatic, peripheric paralysis of face. Distortion of muscles of human face upwards as well as hard speech. Sensation of cobweb over the face.
CURARE 200- It is a peachy remedy for paralysis of diverse kinds as well as of diverse parts of our body. General paralysis of motor system. Ptosis. Facial as well as buccal paralysis. Paralytic failure of mightiness to swallow. Paralysis of deltoid muscles.
ARNICA MONTANA 200-Paralysis due to exudation inside the encephalon or spine. Paralysis inwards lawsuit of apoplexy, of concussion, of weakening illness as well as of protracted intermittent fevers. Paralysis of human face upwards as well as lower lip hang down. Lower lip trembling piece eating.
CONIUM MACULATUM 200- Paralysis from periphery upwards, of onetime women. Speech hard from paralysis of tongue. Distortion of natural language as well as mouth. Food goes downwardly the incorrect way as well as stops piece swallowing. Paralysis of lower limbs than of upper limbs. Staggering < turning the caput or looking sideways.
PLUMBUM IODATUM 200-Plumbum iodatum has been used empirically inwards diverse forms of paralysis. Sclerotic degeneration, specially of spinal cord. Atrophies.
ARSENIC ALB. 200- Paralysis associated alongside peachy prostration as well as neuralgic pains. Spinal affection alongside gressus gallinaceus. Twitching of muscles of face. Paralysis as well as contraction of limbs.
BARYTA CARBONICUM 200- Causes paralysis past times producing degeneration of the coats of the blood vessels. Facial paralysis. Paralysis of onetime people. Paralysis after apoplexy. Facial paralysis of immature people where the natural language is implicated.
NATRUM MURIATICUM 200- Paralysis from cold. Numbness. Tingling of natural language as well as lips. Loss of taste. Tongue striped along the edge. Numbness as well as stiffness ofone side of the tongue. Tongue heavy as well as hard speech. Tongue feels dry out but genuinely non dry. Uvula hangs to ane side. Food goes downwardly the incorrect way. Post diphtheritic paralysis. Fluids tin live on swallowed. Paralytic status of lower limbs.
PHOSPHORUS 200- Paralysis from obese degeneration of nervus cells. Progressive spinal paralysis. Ascending sensory as well as motor paralysis from ends of fingers as well as toes. Arms as well as hands travel numb. Fingers experience similar thumb.Can prevarication on correct side. Post diphtheritic paralysis. Tottery gait Periodical contractions of fingers every bit from cramps