Cancer types such equally melanoma, prostate cancer as well as for certain types of leukemia weaken the trunk yesteryear over-activating the natural immune system. Researchers from the University of Copenhagen bring right away demonstrated that selenium -- naturally constitute in, e.g., garlic as well as broccoli -- slows downward the immune over-response. In the long term, this may improve cancer treatment. The findings bring been published inwards the Journal of Biological Chemistry.
The immune organisation is designed to withdraw things non usually constitute inwards the body. Cells undergoing change, e.g. precursors of cancer cells, are hence usually recognised as well as removed yesteryear the immune system. Unfortunately, the unlike cancer cells incorporate mechanisms that block the immune system's mightiness to recognise them, allowing them to freely proceed cancer development.
Certain cancer cells overexpress immunostimulatory molecules inwards liquid form. Such over-stimulation has a negative impact on the immune system:
"You tin plough over the axe say that the stimulating molecules over-activate the immune organisation as well as drive it to collapse, as well as nosotros are, of course, interested inwards blocking this mechanism. We bring right away shown that for certain selenium compounds, which are naturally constitute in, e.g., garlic as well as broccoli, effectively block the exceptional immunostimulatory molecule that plays a serious run for aggressive cancers such equally melanoma, prostate cancer as well as for certain types of leukemia," says Professor Søren Skov, Department of Veterinary Disease Biology, University of Copenhagen.
Dissolved molecules
In this study, the researchers are focusing on the so-called NGK2D ligands. There are 8 variants, of which ane inwards detail has caught the researchers' attention, because it assumes liquid form. It is exactly the molecular dissolution that causes serious problems, ane time the cancer is raging. The entire bloodstream is, as well as so to speak, infected, as well as the molecule is hence used equally a mark of serious illness:
"Molecules are constitute both on the surface of the cancer cells as well as dissolved inwards the blood of the affected person. We are right away able to demo that selenium compounds seem to bring a rattling beneficial lawsuit when it comes to neutralising the exceptional variant of the NGK2D ligand -- both inwards soluble shape as well as when the molecule is placed on the jail cellular telephone surface," says Professor Søren Skov.
Better drugs inwards future
The researchers are constantly learning to a greater extent than close the affliction mechanisms causing aggressive cancers inwards the skin, blood as well as reproductive organs:
"The overexpression seen inwards cancers such equally melanoma, prostate cancer as well as for certain types of leukemia significantly impairs the immune system. If nosotros tin plough over the axe detect ways to dull downward the over-stimulation, nosotros are on the correct track. The novel results are silent about other pocket-sized measuring towards improve cancer drugs amongst fewer adverse effects," says Søren Skov.