Using fewer than 20 genomes, researchers were unable to uncovering rare protein-altering variants significantly associated amongst extreme longevity, according to a study published Nov 12, 2014 inwards the open-access journal PLOS ONE by Hinco Gierman from Stanford University together with colleagues
Supercentenarians are the world's oldest people, living beyond 110 years of age. Seventy-four are endure worldwide, amongst twenty-two living inwards the United States. The authors of this study performed whole-genome sequencing on 17 supercentenarians to explore the genetic reason underlying extreme human longevity.
From this pocket-sized sample size, the researchers were unable to uncovering rare protein-altering variants significantly associated amongst extreme longevity compared to command genomes. However, they did uncovering that ane supercentenarian carries a variant associated amongst a view condition, which had lilliputian or no number on his/her health, equally this someone lived over 110 years.
The authors added that it is recommended yesteryear the American College of Medical Genetics together with Genomics to written report the results to this private equally an incidental finding. Although the authors didn't uncovering pregnant association amongst extreme longevity, the authors accept publicly published the genomes, making them available equally a resources for futurity studies on the genetic reason of extreme longevity.
This run was supported yesteryear the Ellison Medical Foundation/American Federation for Aging Research Fellowship, Stanford Dean's Fellowship, The Paul Glenn Foundation Biology of Aging Seed Grant, National Institute of General Medical Sciences Center for Systems Biology (P50 GM076547) together with the University of Grand Duchy of Luxembourg - Institute for Systems Biology Program. The funders had no usage inwards study design, information collection together with analysis, determination to publish, or grooming of the manuscript.